Protein Details: Neuronal acetylcholine receptor subunit alpha-4

Protein ID

ICDB_Pro_0989

Protein Name

Neuronal acetylcholine receptor subunit alpha-4

Gene Name

CHRNA4

Organism

Pan troglodytes (Chimpanzee)

Length

627 amino acids

AlphaFoldDB

AF-Q5IS77-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCIPLDVPAEPGPSCKSPSDQLPAQQPLEAEKASPHASPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEGGIRCRSRSIQYCVPRDDATSEAGGQAAGALASRNTHSAELPPPDRPSPCKCTCKKEPSSVSPSATVKARSTKAPPRHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1016/j.cell.2004.11.040

RefSeq

NP_001029107.1; XP_009453308.1